Not only was he ruled out for Sunday's game against the Washington Football Team earlier this week, the soonest Mixon will be able to return is Week 14 against the Dallas Cowboys, as NFL insider Adam Kaplan tweeted that the Bengals have placed Mixon on IR.
As much as the team has downplayed the severity of the injury, it's certainly possible that Mixon could miss the remainder of the season, especially given the team's 2-6-1 record.
That means that Giovani Bernard, available in 32% of Yahoo! leagues on Saturday afternoon, should be picked up immediately if still available in your league.
Ranked as an RB2 in our Week 11 fantasy football rankings, Bernard has averaged 14.1 half-PPR fantasy points per game in the four games that Mixon has missed already. Aside from last week's modest performance (RB30) against the Pittsburgh Steelers, Bernard had finished as fantasy's weekly RB20, RB7 and RB2 in the previous three weeks, respectively.
For deeper leaguers, Samaje Perine is worth a look as well. Perine has 19 touches over the past two weeks and has performed as fantasy's RB22 in Week 8 and RB33 in Week 10 (team had a Week 9 bye).