With that said, here are Sean Beazley's Week 16 NFL picks against the spread:
Tennessee Titans +6.5 over Los Angeles Rams (5 units)- Note: All of our NFL picks against the spread will be centralized here.
The Titans haven’t lost at home since Week 1 vs. the Raiders. Had this game been in L.A., I would pound the other side; but not in Nashville, and not with a playoff berth on the line. I also believe Mike Mularkey is coaching for his job, as there has been a lot of backlash over decisions he and his staff (mainly OC Terry Robiske) have made. I am a homer, but I love this spot getting almost a TD. I think the Titans win outright and I will have some on the money line as well. Titans 27, Rams 23.
Jacksonville Jaguars -4.5 over San Francisco 49ers (5 units)
Jimmy G, meet a real NFL defense. If you told me that the Jags would be where they are now at the start of the season, I would have laughed in your face. This team is going to be extremely dangerous in the playoffs, especially with Blake Bortles playing well. Jaguars defense is too much. Jags 26, 49ers 16.
Cardinals vs. Giants, Over 39.5 (5 units)
This is one of my favorite games to target in GPPs this week in daily fantasy sports (DFS), especially in the late 4 PM slate as everyone will be targeting the Dallas/Seattle game. I think there are going to be a lot of points scored in this one and my bold prediction is this game goes over by 20 points. Cardinals 31, Giants 28.
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